Quadrate in Mannheim, Baden-Württemberg, Germany — Central Europe

Mannheim-Gen

2005

Photographed By James Hulse, February 20, 2024

1. Mannheim-Gen Marker

Inscription. Click to hear the inscription.

German:
Unter Leitung von Prof. Dr. Fokko Van der Woude wurde im Jahr 2005 eine wichtige genetische Ursache des Nierenversagens bei Diabetes entschlüsselt. Die als „Mannheim-Gen" benannte Variante des Gens CNDIRI bewirkt, dass nur in gerinyem Umfang ein Enzym produziert wird, welches das nierenschutzende Eiweil Carnosin aufspaltet. Die Er kennung des Gens hilft Diabetikern, ihr individuelles Risiko einer Nierenschädigung abzuschätzen.

English:
Under the direction of Prof. Dr. Fokko Van der Woude discovered an important genetic cause of kidney failure in diabetes in 2005. The variant of the CNDIRI gene, known as the “Mannheim gene,” means that an enzyme that breaks down the kidney-protecting protein carnosine is only produced to a limited extent. Recognition of the gene helps diabetics to estimate their individual risk of kidney damage.

Erected by Metropolregion Rhein-Neckar and Bouwfonds.

Topics. This historical marker is listed in this topic list: Science & Medicine. A significant historical year for this entry is 2005.

Location. 49° 29.033′

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N, 8° 27.839′ E. Marker is in Mannheim, Baden-Württemberg. It is in Quadrate. Marker is on Bismarckstraße just east of Kurpfalzstraße, on the right when traveling east. The marker is located along the sidewalk in front of the University of Mannheim. Touch for map. Marker is in this post office area: Mannheim BW 68161, Germany. Touch for directions.

Other nearby markers. At least 8 other markers are within walking distance of this marker. SAP (here, next to this marker); Pepperl+Fuchs (a few steps from this marker); Rudolf Fuchs (a few steps from this marker); Prof. Dr.-Ing. Karl Friedrich Marguerre (within shouting distance of this marker); Julius Hatry (within shouting distance of this marker); Hugo Stotz (within shouting distance of this marker); Bulldog (within shouting distance of this marker); Nobelpreis für Medizin / Nobel Prize for Medicine (within shouting distance of this marker). Touch for a list and map of all markers in Mannheim.

More about this marker. The bronze plaque is one of 42 plaques set up along the “Electoral Palatinate Mile of Innovations” in front of Mannheim Palace.

Also see . . . 2005 Mannheim gene. Kurpfälzer Mile of Innovations

With his license to practice as an internist, he begins his scientific career. He becomes assistant in nephrology at the University of Groningen and trains from 1982 to 1985 to become a nephrologist, a specialist in
Photographed By James Hulse, February 20, 2024

2. The view of the Mannheim-Gen Marker along the sideway
renal medicine. While still in residency, he began researching immune complexes. He discovered that the serum of patients suffering from "Wegener's granulomatosis" (an inflammatory rheumatic autoimmune disease of the vascular system with frequent kidney inflammation) adheres to the neutrophil granulocytes in a very special way. Neutrophil granulocytes form the largest subgroup of white blood cells and are part of the cellular immune system.

(Submitted on February 24, 2024, by James Hulse of Medina, Texas.)

Credits. This page was last revised on February 24, 2024. It was originally submitted on February 24, 2024, by James Hulse of Medina, Texas. This page has been viewed 38 times since then. Photos: 1, 2. submitted on February 24, 2024, by James Hulse of Medina, Texas.