St. Charles in St. Charles County, Missouri — The American Midwest (Upper Plains)

315 N. Sixth Street

— Midtown Neighborhood —

Photographed by Duane and Tracy Marsteller, July 20, 2024

1. 315 N. Sixth Street Marker

Inscription. This house was built 1858-1859 and has been referenced as “the first house in this area”. Original owner/builder was Joseph Mueller who migrated from Germany and sent for his wife, Theresa, after the house was completed. Theresa resided here until her death in 1929.

The house was constructed with no fireplace. and initially had a summer kitchen that no longer stands. Few modifications have been made to the original structure. It features the original front windows.

A special owner of the home for over 30 years (1955-1966) was Dr. Mary Talbot, a professor of entomology at Lindenwood College. Dr. Talbot dedicated her life to teaching and researching ants for over 50 years. Her observations were published in numerous scientific journals.

Topics and series. This historical marker is listed in these topic lists: Architecture • Education • Science & Medicine. In addition, it is included in the National Register of Historic Places (NRHP) series list. A significant historical year for this entry is 1858.

Location. 38° 47.139′ N, 90° 29.24′ W. Marker is in St. Charles, Missouri, in St. Charles County.

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It is on North 6th Street south of Adams Street, on the right when traveling south. Touch for map. Marker is at or near this postal address: 315 N 6th St, Saint Charles MO 63301, United States of America. Touch for directions.

Regionally, this marker is in the Missouri River Corridor

and in Greater St. Louis.

It is also in the American Midwest,

in the Lewis & Clark Corridor,

in the Corn Belt,

and in the Great River Road Region.

Globally, it is in North America,

the Western Hemisphere,

the Western World,

and the Anglosphere.

Historically, it finds itself in what was once the territory of the Mississippian Culture,

the Louisiana Purchase,

and the Antebellum South.

Other nearby markers. At least 8 other markers are within walking distance of this marker: 317 North Sixth Street (a few steps from this marker); 320-322 North Sixth Street (a few steps from this marker); 321 North Benton (about 400 feet away, measured in a direct line); 616 Washington Street (about 500 feet away); Circa 1864 (about 600 feet away); 705 Washington Street (about 700 feet away); 1891 (about 700 feet away); 721 Washington Street (about 700 feet

Photographed by Duane and Tracy Marsteller, July 20, 2024

2. 315 N. Sixth Street Marker

away). Touch for a list and map of all markers in St. Charles.

Also see . . . Midtown Neighborhood Historic District. Wikipedia entry:
Links to National Register of Historic Places Registration Form (Submitted on October 30, 2025, by Larry Gertner of New York, New York.)

Credits. This page was last revised on October 30, 2025. It was originally submitted on August 15, 2024, by Duane and Tracy Marsteller of Murfreesboro, Tennessee. This page has been viewed 182 times since then and 21 times this year. Photos: 1, 2. submitted on August 15, 2024, by Duane and Tracy Marsteller of Murfreesboro, Tennessee.