Near Nelson in Saline County, Missouri — The American Midwest (Upper Plains)
Sappington Cemetery State Historic Site
Dr. John Sappington (1776-1856) was born in Virginia. In 1804, he married Jane Breathitt (1783-1852), who was from a prominent Kentucky family. By 1819, they had settled in Saline County, Missouri. His family achieved prominence and wealth through his business and medical enterprises. In 1832, he experimented with the bark of the Peruvian cinchona tree, which was known for its fever-reducing qualities. From that bark, he isolated a compound called quinine, which he massmarketed in pill form to treat malarial fevers. An education fund started by the doctor continues today as a college scholarship.
Sappington Cemetery
Stone sarcophagi over the graves of Dr. John and Jane Sappington. His inscription reads "A truly honest man is the noblest work of God. He lay like a warrior taking his rest." Her inscription reads "Mrs. Jane Sappington consort of Dr. John Sappington."
Sappington Negro Cemetery
Around 1856, Sappington gave two acres of land to Emanuel Banks, an enslaved man, to be used as a cemetery. From the mid-19th century to mid-20th century, about 350 African-Americans from the Arrow Rock area were buried in that cemetery.
A Family Dynasty
The Sappington family dynasty included three Missouri governors. Two are buried here.
Meredith Miles Marmaduke (1791-1864) was elected Lt. Governor in 1840 and became Missouri's eighth governor upon the death of Gov. Thomas Reynolds in 1844. Marmaduke was a Santa Fe trader from 1824 to 1830 and was married to Dr. John Sappington's daughter Lavinia in 1826. Their son, John Sappington Marmaduke, became Missouri's 25th governor in 1885. Unlike many of his family members, Meredith Marmaduke supported the Union during the Civil War.
Sappington Cemetery
Monument of Gov. Meredith and Lavinia Marmaduke. The arch symbolizes victory over death and the clasped hands a farewell and a hope of meeting in eternity. The Masonic compass signifies his membership status as a Freemason.
Claiborne Fox Jackson (1806-1862) was beginning his term as Missouri's 15th governor at the start of the American Civil War. Jackson supported slavery and the secession of Missouri from the United States. He died while in exile in Little Rock, Ark., and was reburied here following the war. Jackson married three of Dr. Sappington's daughters in succession: Jane in 1831 (died 1832), Louisa in 1833 (died 1838) and Eliza in 1838 (died 1864.)
Sappington Cemetery
Monument of Gov. Claiborne and Eliza Jackson. The classical style columns symbolize "noble qualities" attributed to the life of the Jacksons.
John Sappington Marmaduke (1833-1887) was elected as Missouri's 25th governor in 1885. Prior to winning the election, he played a major role in the American Civil War.
Woodland-Old City Cemetery, Jefferson City, Mo.
Monument of Gov. John Sappington Marmaduke. His inscription includes " Yale College three years. Harvard College one year. Graduate of West Point Military Academy. Lieutenant in the United States Army, Captain and Colonel, MO. State Guard, Brigadier General and Major General, Confederate States Army. Secretary State Board of Agriculture. Railroad Commissioner of MO and died while Governor of Missouri, December 28, 1887 "
Erected by Missouri State Parks.
Topics. This historical marker is listed in these topic lists: Cemeteries & Burial Sites • Science & Medicine • War, US Civil. A significant historical date for this entry is December 28, 1831.
Location. 39° 1.962′ N, 93° 0.456′ W. Marker is near Nelson, Missouri, in Saline County. It is on Missouri Route AA Spur half a mile south of Route AA, on the right when traveling south. Marker is located outside the cemetery. Touch for map. Marker is at or near this postal address: State Hwy AA Spur, Nelson MO 65347, United States of America. Touch for directions.
Regionally, this marker is in the Missouri River Corridor. It is also in the American Midwest, in the Lewis & Clark Corridor, in the Corn Belt, and on the Santa Fe Trail Corridor. Globally, it is in North America, the Western Hemisphere, the Western World, and the Anglosphere. Historically, it finds itself in what was once the territory of the Mississippian Culture, the Louisiana Purchase, and the Antebellum South.
Other nearby markers. At least 8 other markers are within 2 miles of this marker, measured as the crow flies: A different marker also named Sappington Cemetery State Historic Site (within shouting distance of this marker); Sappington Negro Cemetery (approx. 0.4 miles away); Enslavement to Freedom (approx. 0.4 miles away); Sappington African American Cemetery Burials (approx. 0.4 miles away); Segregation in Life and Death (approx. 0.4 miles away); Brownlee School (approx. 0.6 miles away); The Sanders A.H. Townsend House (approx. 0.9 miles away); "Prairie Park" (approx. 1.3 miles away). Touch for a list and map of all markers in Nelson.
Also see . . .
1. Sappington Cemetery State Historic Site. Missouri State Parks website entry (Submitted on May 17, 2024, by Jason Voigt of Glen Carbon, Illinois.)
2. Sappington Cemetery State Historic Site. Wikipedia entry (Submitted on May 17, 2024, by Jason Voigt of Glen Carbon, Illinois.)
Credits. This page was last revised on December 11, 2025. It was originally submitted on May 17, 2024, by Jason Voigt of Glen Carbon, Illinois. This page has been viewed 404 times since then and 32 times this year. Photos: 1, 2. submitted on May 17, 2024, by Jason Voigt of Glen Carbon, Illinois.

