Orangeburg is the county seat for Orangeburg County
Adjacent to Orangeburg County, South Carolina
Aiken County (131) ► Bamberg County (38) ► Barnwell County (44) ► Berkeley County (96) ► Calhoun County (18) ► Clarendon County (66) ► Colleton County (48) ► Dorchester County (49) ► Lexington County (67) ►
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| On Bowman Branch Hwy (State Highway 210), on the right when traveling west. |
| On Charleston Highway (U.S. 178) near Park Street, on the right when traveling north. |
| On Charleston Highway (U.S. 178) near Park Street, on the right when traveling north. |
| On Charleston Highway (U.S. 178) near Park Street, on the right when traveling north. |
| On Freedom Blvd. (US 21) at Freedom Rd. (US 21), on the right when traveling north on Freedom Blvd. (US 21). |
| On Freedom Boulevard (U.S. 21) near East Railroad Avenue, on the right. |
| On U.S. 21, on the right when traveling north. |
| On Neeses Highway (State Highway 4) 0.5 miles west of Old Edisto Road (U.S. 301), on the right when traveling west. |
| On Bamberg Rd ( US-301 / US-601) near Zion Church Rd., on the left when traveling north. |
| On State Highway 6, on the right when traveling west. |
| On West Cleveland Street (State Highway 47) near Church Street, on the right when traveling south. |
| On Main Street (State Roads 6, 267), on the right when traveling west. |
| On East Hampton Street at North Lexington Street, on the left when traveling east on East Hampton Street. |
| On Old Number Six Highway (State Highway 6 / 45) near Fredcon Road. |
| On Old Number Six Highway (State Highway 6 / 45) at Fredcon Road, on the left when traveling east on Old Number Six Highway. |
| On Old Number Six Highway (State Highway 6 / 45) near Fredcon Road, on the left when traveling east. |
| Near Old Number Six Highway (State Highway 6 / 45) at Fredcon Road, on the left when traveling east. |
| Near Old Number Six Highway ( SC-6, SC-45) near Fredcon Road, on the left when traveling east. |
| On Eutaw Highway (State Highway 45) at Old Number Six Highway (State Highway 6), on the right when traveling west on Eutaw Highway. |
| On Old Number Six Highway (State Highway 6 / 45) near Fredcon Road, on the left when traveling east. |
| Near Old Number Six Highway (State Highway 6 / 45) near Fredcon Road, on the left when traveling east. |
| On State Street (U.S. 176) at Depot Street, on the left when traveling east on State Street. |
| On State Street (U.S. 176) at Eutaw Road (State Highway 453), on the right when traveling south on State Street. |
| On Branch Ford Road (State Highway 314) near Target Road (State Highway 38-68), on the right when traveling east. |
| On Interstate 26 near Interstate 95, on the right when traveling west. |
| On Waterspring Road (State Highway 38-142) near Lime Kiln Road, on the left when traveling east. |
| On Ninety Six Road (John Nunn Highway) (State Highway 389) near Coldstream Road (County Road 933), on the right when traveling north. |
| On Rice Street at Silver Springs Road, on the left when traveling west on Rice Street. |
| On Norway Road (County Highway 332) 0.3 miles west of Trojan Street (County Highway 2218), on the right when traveling west. |
| On North Road (Moorefield Memorial Highway) (U.S. 178), on the right when traveling east. |
| On North Road (U.S. 178) at Main Street West (U.S. 321), on the left when traveling west on North Road. Reported unreadable. |
| On Riverside Dr SW, on the right when traveling north. |
| On Belleville Road (State Highway 38-29), on the right when traveling west. |
| On Russell Street (State Highway 33) at Lowman Street, on the right when traveling east on Russell Street. |
| On Claflin Circle east of Magnolia Street (U.S. 601), on the left when traveling east. |
| On Claflin Circle, on the right when traveling east. |
| On John C. Calhoun Drive (U.S. 301) at Russell Street (State Route 33), in the median on John C. Calhoun Drive. |
| On Church Street near Russell Street (State Road 33). |
| On Riverside Drive SW (South Carolina Route 125) 0.1 miles west of Seaboard Street NW (South Carolina Route 126), on the right when traveling west. |
| On Boulevard Street, NE, on the right when traveling south. |
| On Geathers Street east of Desaussure Circle, on the right when traveling east. |
| On Neeses Highway (State Highway 4) near State Rd S-38-1695 (State Highway 38-1695), on the right when traveling west. |
| On Rowesville Road (U.S. 21) at South Carolina Highway S-38-57, on the right when traveling south on Rowesville Road. |
| On Russell Street (State Highway 33) east of Broughton Street (Business U.S. 178), on the left when traveling east. |
| On Whitman Street, on the left when traveling east. |
| On Columbia Road Northeast at Valencia Drive, on the right when traveling south on Columbia Road Northeast. |
| On Charleston Highway (U.S. 178), on the right when traveling east. |
| On Bull Street (State Road 38-1061), on the right when traveling west. |
| On Russell Street (State Highway 33) near Church Street, on the right when traveling west. |
| On Riverside Drive, on the left when traveling north. |
| On Willington Drive Northeast, 0.1 miles north of Prep Street, on the right when traveling north. |
| On Bull Street (State Road 38-1061), on the right when traveling west. |
| On Magnolia Street (U.S. 601) at Geathers Street, on the right when traveling north on Magnolia Street. |
| On South Carolina Route S38226 north of Russell Street (Route 33), on the right when traveling north. |
| On Watson Street (State Highway 38-226) just south of Gathers Street, on the left when traveling south. |
| Near Russell Street (State Highway 33), on the right when traveling south. |
| On Boulevard Street (State Highway 38-25) near Amelia Street (State Highway 38-70), on the right when traveling south. |
| On Riverside Drive at Russell Street, in the median on Riverside Drive. |
| On Riverside Drive, on the left when traveling south. |
| On Five Chop Road (U.S. 301), on the right when traveling west. |
| On Belleville Road (South Carolina Route S-38-29) at Mingo Street, on the right when traveling south on Belleville Road. |
| On Glover Street near Middleton Street, on the right when traveling east. |
| On Landsdowne Road (State Highway 38-92). |
| On Old State Road (U.S. 176) east of Vance Road (State Highway 210), on the right when traveling west. |
| On Old State Road (U.S. 176) near Vance Road (South Carolina Highway 210), on the right when traveling west. |
| Near Interstate 95 at milepost 99,, 0.6 miles north of Old Number Six Highway (U.S. 15), on the right when traveling south. |
| On Neeses Highway, 0.3 miles east of Kyzer Brown Road, on the right when traveling east. |